Normothermic Systemic Life
(Dry: +37C to +32C)
Hypothermic Cellular Life
(Dry:+31C to +5C / Wet: +4C to -20C)
Cryothermic Atomic and Genetic Life
(Dry Freeze: -20 to -40C)
Normothermic Informatic Life
(Dry Environment Temperature:10C to 30C)
Blood, O2, Water, Nutrients, Hormones
Sugar, Minerals, Salt, Protein, CO2, N2
Photonic,Electric,Magnetic Nano Particles
Chemical, Photonic, Electric, Magnetic
Nano Catheter, Scalpel, Laser, Claw, Robots
Vaccines, White Blood Cells, Antibiotics
DNA Transfer, DNA Reprogramming
Cell Replacement, Cell Reproduction
DNA, Gamete, Blood, Stem Cells
Text, Audio, Video Interface
Permanent Life Module (PLM) is a low cost, high performance, multi application product, with high economies of scale and scope. Preserves, regresses, regenerates and progresses Systemic, Cellular, Atomic, Genetic and Informatic Life. Price target of US$9995 + US$95 month for a target market of over 7 billion Humans.
A biochemic-infotronic product (bioengineering, biogenetic, bioinformatic, bioelectronic, cryobiology, microbiology, microfluids, biomedicine and nanomedicine) systematizing multi techniques/services/products into one device that can be mass produced (economies of scale), have multi functions (economies of scope), with control/storage/network integrated capacity to receive/deliver information, energy and fluids.
It's crucial to have the technology to regress/progress stages of life within the same device because of cultural, philosophical, scientific differences/inefficiencies/discoordinations leading to the abandonment of Systemic, Cellular, Atomic, Genetic, Informatic Life and eventual non-identifiable partial atomic/molecular dispersion. This is typical of current mortuary, medical, legal and religious procedures, usually leaving only skeleton or ashes, with loss of Identifiable Permanent Life (if also Genetic and Informatic Life are not preserved).
The Permanent Life Module mobile body posture (also applicable to bed sleeping posture) is an upper body 30 degree angle and lower body 10 degree angle, laying on back, because of the gravity effect on the circulatory, respiratory and immune system: better brain to feet circulation (oxygen/nutrition supply to cells) and flow down/out of defensive mucus/fluids/pathogens avoiding stagnation and spread of infection. Also allows for gravity swing circulation enhancement.
All hospitals, clinics, ambulances, organizations and events with large concentration of individuals should have a PLM. Eventually all individuals should have their individual PLM in their place of work and/or at their residence. Initially Patients can retrieve blood and other fluids for preventive testing, to harvest stem and immune cells, to be replicated and cryopreserved in a bank for immediate economic use, when needed, as adding antigen and nuclear transfers, to eliminate any viral/bacterial infection, cancer or injury to cells and tissues.
Individual Universal Immunotherapy (IUI) can eliminate viruses, bacteria and cancer at the lowest cost and highest performance in the healthcare industry: blood extraction with pathogen, infected cell and white cells; additional extractions, with centrifuge separating white cells (added to the first extraction), red cells (oxygenated/ozonated) and plasma (add nutrition/supplements).
1) SYSTEMIC LIFE SUB-MODULE (SYSTEMIC PROTECTION-REGENERATION):
Micro Lab (microfluid anaylsis as blood, saliva and urine);
Micro Immunity (Individual Universal Immunotherapy, vaccines, cell nano markers);
Micro Nutrition (blood oxygen, glucose and hormones);
Micro Filtration (blood filtration);
Micro Screen (direct interaction with information database and doctors);
Micro Imaging (ultrasound/magnetic resonance image: bones, muscles and tissues),
Micro Probe (blood-vessel or inter-cellular nano catheter/robot diagnostic and treatment).
Average life expectancy has been consistently advancing and when it reaches around the average point, Systemic Life protection must be applied to extend life further and potentially forever. Bone, muscle, tissue, organ and brain deterioration from supposed "aging", leading to mobility and/or intellectual capacity reduction (specially because of use of neurological drugs and lack of activity), to cardiorespiratory stoppage, to neurological stoppage and supposed "death" can be delayed and reversed. Currently 85 to 95 years is the usual age treatment interval in terms of cost-benefit, where there is nothing to lose and everything to gain if there is significant reduction of mobility and/or intellectual capacity.
Cells can divide/grow indefinitely if the cell telomere (end of the chromosomes) has adequate size, induced by the telomerase enzyme, which in turn is induced by hormones. Neural cells (produced until 6 years and potentially after) and cardiac muscle cells (renewed 0.3% to 1% based on carbon dating) do not have a fixed life time, can grow in size, can survive indefinitely (if not destroyed by neurological drugs, cancer, virus, bacteria and have adequate protection), can be replaced/recovered by internal stimulus (regeneration/repair enzymes/hormones) and/or external introduction of stem/repair/replace cells (bio cells, nanobots and artificial cells). Individuals considered "dead" by primitive traditional medicine have 99.99% living cells and healthy neurons similar to the time of infancy (unless neurons are affected by the collateral effect of neurological drugs or polution).
Systemic Life should be preserved with physical/mental activity and nutritional / hormonal / immunological supplements: bio-specific (anti-cancer/viruses/bacteria vaccines) and bio-identical white cells/hormones (same DNA); sensitive/selective cellular nanomarking (photo-thermal / electromagnetic / biochemical); growth of specific tissue/organ with stem cells via nuclear transfer or genetic reprogramming/pluripotency to accelerate the growth of healthy cells and suppress the growth of unhealthy cells. Anomalies such as cancer, weak regrown muscle or ventricular heart defect can be prevented with bio-identical hormones/vaccines, supplementary nutrition/exercise, monitoring and/or corrective intervention.
The Systemic Life sub-module should offer support for the permanent preservation and regeneration of cells; reinforcement of immune system to combat damaging virus, bacteria and cancer (antibiotics and vaccination: externally/internally induced combat-specific bio-identical white cells and unhealthy cell nanomarkers to accelerate signal to white cells); micro-fluid testing (blood, saliva, urine etc.); micro magnetic resonance and ultra sound examination (bone, muscle, tendon and tissue); tissue/organ/cell regeneration, construction and transplantation; nano, micro and macro surgery; nutritional/hormonal/immunological supplements; orthopedic/neurologic/circulatory (pressure/counter-pressure) exoskeleton; photo / magnetic / electric / chemical / bio (positive virus/bacteria gene changer) sensitive cell nanomarkers/ nanorobots/ nanosponges (soak up hydrogel w/red cell membrane) to eliminate unhealthy cells or position new healthy modified cells derived from stem cells.
Pluripotent cells can be any kind of cell via cell DNA reprogramming of pluripotency genes Oct4/Pou5f1, Sox2, cMyc and Klf4 (IPSC: Induced Pluripotent Stem Cells); cell reproduction via DNA nuclear transfer to new oocytes (SCNT: Somatic Cell Nuclear Transfer); genetic engineering with nano-robots and/or bio-robots (CRISPR/TALEN/ZFN/MAGE etc.); permanent regeneration with unlimited controllable mitosis stopping shortening telomeres at end of chromosomes that limit mitosis to around 50, via gene/enzyme (HTert/Telomerase Reverse Transcriptase) and/or via growth hormones.
An immune supplemental system should simultaneously combine cell markers (enhance cancer, viral and bacterial cell signaling to the immune system), immunological checkpoint protectors (deactivated/inhibited by harmful agents), indirect vaccines (immune system specific activating alarm against harmful cells) and direct vaccines (introduction of pre-activated immune cells against specific harmful cells).
There can be also a combination of bio-chemical, electro-magnetic and/or photonic nanomarkers with bio-identical anti-cancer / viral / bacterial vaccines and/or destroyers/builders of marked cells. The photo/ electro-magnetic sensitive nanomarker of unhealthy cells can destroy them by subsequent thermal photo / electro-magnetic stimulus (laser, microwave and/or electro-magnetic current/wave). Healthy cells derived from stem cells can also be marked, for example with nano magnetic biodegradable substance, and conducted to a specific site, through the bloodstream, to the region marked by the magnetic field.
The current traditional chemo radioactive anticancer system is expensive, has efficiency limited to early tumors and significant side effects, including lethal, while also attacking healthy cells. Brachytherapy, short distance micro radiation, introducing radioactive micro seeds with a catheter, directly on/near the tumor, are more efficient with reduced collateral effect. The current governmental bureaucratic system of approval of patented treatments is inefficient/damaging and seeks the primary interest of enterprises and secondarily of the patients that should be treated with multiple simultaneous systems, theoretically more efficient, to be verified empirically.
In new systems, phosphoethanolamine for example could be used as a bio-chemical marker because it participates in the formation of cell membranes that include proteins. This substance or any other that accelerates the placement of signaling proteins/proteases (such as interleukin/caspase) or dysfunctional (cancerous) in the cell membrane, would lead to an acceleration in the marking or identification of this cell as cancerous by the immune system.
If additionally white cells of the patient with cancer are removed and exposed to cancer markers, they will immediately be conditioned/prepared to attack these unhealthy cells when reintroduced into the bloodstream. If a biodegradable magnetic nanomarker is added to the white cells and a magnetic field of attraction is placed, these cells will be attracted to the cancer region quicker, whose marking has been also accelerated by the phosphoethanolamine (in addition to a protector against inhibitors/deactivators of immune cell checkpoints), destroying cancer cells immediately and efficiently. Bio-identical healthy cells derived from stem cells can also be conducted to the affected area to repair the tissue / organ.
Electric and photonic currents/waves are currently used in Life preserving systems. Gravitonic currents/waves (sub-photonic graviton energy-matter quantum) would expand the possibilities even further with human complete automated cellular diagnostics and treatment, identifying all healthy and unhealthy cells to be repaired or eliminated by cell markers, multi energy quantum waves and/or nanorobots.
2) CELLULAR LIFE SUB-MODULE (VASCULAR EXO-CIRCULATION):
AEROHEART, AUTOMATED EXTERNAL VASCULAR CIRCULATION, ELECTRIC EXOSKELETON NEURO-MUSCULAR STIMULATOR AND COMPRESSION PULSATION BELT PNEUMATIC BODY SUIT, RESPIRATION VACUUM-AIR PUMP, GRAVITY SWING PLATFORM, BLOOD OXYGENATION- NUTRITION- FILTRATION, ELETRODE-ELETROCHEMICAL STIMULATOR, REFRIGERATION FOR THE REDUCTION OF CELLULAR OXYGEN CONSUMPTION, EXTERNAL/INTERNAL AIR-VACUUM PRESSURE-SUCK BLOOD HEART CIRCULATOR.
If Systemic Life cannot be sustained, in case of cardiorespiratory and neurological stoppage, there will be a regression to Cellular Life that must be protected with artificial systems until progression back to Systemic Life is possible. Cardiorespiratory stoppage from a controllable local hemorrhage/infection/cancer or a vital system/organ damage / dysfunction from trauma, cancer, bacteria or virus (etc), leading to neurological stoppage, can be reversed with artificial cardiorespiratory systems.
Cellular Life must be preserved with external (pulsation suit, chest automatic inflatable belt, chest vertical pump heart pulsation, legs/arms counter-pulsation inflatable belts, automatic electric shock defibrillator, mouth vacuum valve oxygenation and gravitational swing circulation) and/or internal (direct blood nutrition/filtration/immunization/oxygenation heart-lung/kidney machine) mechanical blood circulation/oxygenation (hand heart massage generates only 15% of normal blood circulation and can't be sustained for a long time) and/or reduction of temperature to reduce cell oxygen consumption (50% reduction with each 10 Celsius reduction until +4 Celsius), cardio-muscular and brain-neurological supplementation (body electrodes for maintenance of muscle contraction and electrical neurological flow). If unified general circulation is not possible (because of organ dysfunction and/or localized hemmorrhage/infection/cancer), independent partial/segmented circulation can be used to provide oxygenation, nutrition, filtration, immunization, hormonization and regeneration to the cells.
Generally after 3 to 5 minutes of failed attempts to restart circulatory and respiratory systems, with traditional manual operated cardio-respiratory monitoring and electric/physical stimulus, the patient is declared medically dead by primitive medicine and waits legal death which is when neurological system stops because of the lack of oxygen in cells. Some doctors or primitive medical systems may try temporarily to extend the window to restart the cardio-respiratory system by using automatic external heart stimulator and/or bags of ice, to reduce temperature and cell oxygen consumption. The full possibilities of advanced medicine are not been used to the full extent to preserve Life, mainly for economic reasons and systemic integration inefficiencies.
Gravitational swing carbon fiber full body platform (up-down center leverage), supports a full body exoskeleton that can also be used for full/partial skeleton immobilization for bone fracture recovery and/or electric muscle replacement mobility. Defibrillator and full body electric system (external electrodes / internal electrochemicals) can stimulate muscles, heart, brain, organs and tissues for recovery acceleration and restart of activity. Inflatable pulsation belts placed in exoskeleton give sequential pressure counter circulation to increase arterial/venal circulation flux/reflux from thorax belt pressure on heart.
Belt suit form a full body refrigerated pressure circulation system supported by exoskeleton, connected/synchronized with gravitational swing platform and respiration air pump with thorax vacuum pressure over heart. All devices acting together, and with reduction in cellular oxygen consumption via refrigeration, can increase substantially the efficiency of primitive manual CPR heart massage and air intake blow (from only 15% efficiency compared to normal circulation), sustaining Cellular Life until progression back to Systemic Life.
The Permanent Life Module can be used to extend indefinitely Cellular Life via external/internal cell oxygenation and/or gradual reduction of temperature of patient, reducing cell oxygen consumption by 50% for each 10 Celsius reduction, while maintaining an automated computer guided cardio-respiratory monitoring and physical/electric stimulus. Its Heart-Lung Machine component can replace interior heart/lung indefinitely, or before a potential bio/artificial transplant, or for direct blood temperature reduction for fast body hypothermia as a last resort to reduce cell oxygen consumption before freezing/deactivating cells with transition from Cellular Life to Atomic Life.
Sonic, electric, photonic and/or gravitonic waves can in theory eliminate unhealthy / senile / cancer cells, bacteria and virus by breaking their natural membranes or coated by biochemic an/or nanorobotic markers, while preserving stronger healthy cell membranes (empirical tests must determine the wave density/size/frequency). This may be the last attempt to preserve Cellular Life before regressing to Atomic Life, where the procedure may be repeated, against unhealthy membranes that resist instantaneous freezing generating microcrystals of water, dehydration, thawing and rehydration (markers can unprotect unhealthy membranes while healthy membranes are protected by cryopreservatives such as trehalose).
3) ATOMIC LIFE SUB-MODULE (POROUS EXO-CIRCULATION):
AQUAHEART, CRYOPRESERVATIVE AND BLOOD RESERVOIR, FLASH AND DRY FREEZER,
VIBRATION PLATFORM, ELETROMAGNETIC MICROWAVES, VACUUM DEHYDRATOR, REHYDRATOR, EXTERIOR POROUS PRESSURE-GRAVITY INTERCELLULAR CIRCULATOR.
General hemorrhage/infection/cancer and/or vital organ dysfunction can obstruct unified or segmented vascular circulation, leading to a generalized collapse of the cells. The cells can be deactivated temporarily for their protection, until porous circulation can be added to the obstructed vascular circulation allowing all cells to be reached, sustained and regenerated. Cardiorespiratory stoppage from uncontrollable general hemorrhage/infection/cancer or vital systems/organ damage/dysfunction from trauma, cancer, bacteria or virus (etc), leading to neurological stoppage, can be reversed with cryoprotected flash/dry freeze followed by porous rehydration/circulation, cellular regeneration and progression back to Cellular/Systemic Life.
Atomic Life must be preserved with deactivation of cells (for subsequent reactivation after cell rehydration and regeneration) using cryopreservatives (sugary/saline/ionic solution as phosphate-trehalose to penetrate and protect cellular membranes including internal organelles and nucleus), flash/dry freeze (-20 to -40 Celsius, electromagnetic waves, mechanical vibration, vacuum sublimation, forming a cell structured dry porous sponge) and rehydration (vapor, mist, spray and liquid). Reintroduction of blood (or circulatory solution) including bio-identical/bio-specific hormones and white cells with same DNA (anti-cancer/viral/bacterial vaccines) accelerates growth of healthy cells and suppression of unhealthy cells. Cells will be fed with glucose/oxygen (etc) directly via pores/vases (top to bottom pressure/osmosis/electrolysis/gravity cyclic flux), reestablishing aquatic Cellular Life.
Flash/dry freeze results in a porous dry "sponge" body that can be rehydrated/regenerated via additional porous interstitial/ intercellular high (liquid) to low (vacuum) pressure circulation. Porous Intercellular Circulation can be total, for all the body, or partial, for separated damaged organs, tissues or body segment without vascular circulation, in addition to the partial vascular circulation for the rest of the body. Cells would be added/regenerated by mitosis or by introduction of external stem cells with nano markers/robots to guide them to place and/or use of biodegradable scaffolds to fully assemble organs/tissues. After cell structure regeneration (using also external stem cell introduction if necessary), there will be a transition to external dry Cellular Life with natural/artificial addition of external epidermic keratin to impermeabilize skin, maintaining the vascular mechanical circulation for nutrition/oxygenation of blood. Finally there will be a transition back to the original Systemic Life with the reactivation of the natural circulatory, respiratory and neurologic systems via chemical/electric stimulus.
When Tardigrades (the most resistant animal on Earth) dry out, the glucose in their bodies changes to trehalose, entering cryptobiosis, a state where they appear "dead." But when receiving water, they reactivate the cells and return to their metabolic state. Tardigrades can endure alterations of minus 200 degrees Celsius to plus 150 degrees Celsius, over 30 years without water/food, endure space vacuum, solar heat/radiation, by dehydrating cells, regressing to Atomic Life, back to Cellular Life and Systemic Life, including preserving reproduction capacity. The sea sponges have an intercellular porous circulation of sea water, demonstrating empirically, together with the Tardigrades, the possibilities of cellular, dehydration, rehydration and regeneration.
Atomic Life must be preserved with deactivation/dehydration of cells (for subsequent reactivation after cell rehydration and regeneration) using cryopreservatives (phosphate/sugar-trehalose/saline solution), flash/dry freeze (-40 Celsius, electromagnetic/mechanical vibration, vacuum sublimation, forming a cell structured dry porous sponge) and rehydration (vapor, mist, spray and liquid). If this high tech assisted flash/dry/cryopreserved freezing is not available, Cellular/Atomic Life should be preserved in refrigerator (dry hypothermia +4C), freezer (in saline water to -20 Celsius or in sugar water to -40 C), near Earth's poles or at high mountains, with sugared and/or saline water if possible (frozen water crystal cell membrane rupture is potentially fixable with a specific wet defrosting protocol). Water freeze may lead to cell damaging, but it is better than non preservation, because in theory cell damages can be repaired as well, while a collapsed cell structure at high ambient temperature, followed by atomic dispersion, cannot be repaired with the same atoms that will become unidentifiable in the environment. Multicellular cryopreservation liquid defrost protocol consists of raising temperature from top to bottom cells to avoid mechanical collapse.
4) GENETIC AND INFORMATIC LIFE SUB-MODULE (BIO-BINARY DNA-MEMORY):
MICRO FLASH/DRY FREEZER (bio-DNA preservation),
MICRO HARDRIVE-SOFTWARE (binary DNA and memory).
DNA bio-preserved in frozen/dehydrated cells, allowing identical atoms to be reassembled into identical cell structures of a new identical partial (organs/tissues) or total body ("hardware"), via genetic reprogramming of stem cells, or gamete (oocyte) reproduction by nuclear transfer (twin son/daughter of adults or twin brother/sister of minors). Also a similar brain memory ("software"), transferred directly (neuron interface when possible) or indirectly via binary memory (text / audio / video interface of knowledge, culture and history). Faster invasive direct neural connection and slower non-invasive indirect interface (text/audio/video) have also the alternative of mid-speed hybrid non-invasive sub-conscious/sleep/hypnosis acceleration of input (ear/audio and eye/video/text) and output (mouth/voice/audio and hand/text/image).
Different types of unipotent (fluid, tissue and organ adult cells) or pluripotent cells (embryonic adult and stem cells, such as in umbilical cord blood) must be preserved for potential reprogramming and/or nuclear transfer. Preservation of DNA genetic code for regeneration/reproduction of organ/tissue/fluid cells and/or complete reproduction via nuclear transfer to oocyte for development of twin brother-son or sister-daughter. Over one billion fertile women can produce over twelve billion oocytes a year for dual gamete reproduction, cell nuclear transfer reproduction and/or organ/tissue/fluid/cell regeneration with genetic reprogramming.
PERMANENT LIFE MODULAR PRODUCT
Battery Generator Storage
Energy Network Connection
Heat Refrigerate Freeze
Salt Sugar Protein
PERMANENT LIFE TECHNOLOGY
Permanent Life Module
Normothermic Systemic Life
(Dry: +37C to +32C)
Test Sample Micro laboratory
(blood, saliva, urine, feces, hair, skin etc)
Computer Cardio-Respiratory Monitoring
(ventricular fibrillation/tachycardia: AED + AECP)
(pulseless/asystole: ACPR + ACBS + AECP)
Automated Electric / Physical / Biochemical Stimulator
(Aeroheart: Body Pneumatic Compression Suit)
(AED: Automated External Defibrillator)
(ACPR: Automated Cardio Pulmonary Reactivation)
(ACBS: Automated Cardiac Biochemical Stimulant)
(AECP: Automated Exterior Counter Pulsation)
(external electrodes / internal electrochemicals)
(upper/lower body counter pressure bag-belts)
(gravitational circulatory mechanical swing)
Air / Oxygen Support
(valve to block air reflux)
(brain refrigeration helmet)
(vacuum on chest compression to exhale air)
Hypothermic Cellular Life
(Dry:+31C to +5C / Wet: +4C to -20C)
(+37 Celsius to +4 Celsius)
(-10C = -50% in cellular oxygen consumption)
Exterior Heart-Lung-Kidney Machine
(central and/or segmented blood extracorporeal
oxygenation and nutrition)
(hemodialysis/hemofiltration for water/toxin control)
(replace blood w/ hypo-preservative saline solution)
(replace blood w/ cryo-preservative sugar solution)
(+4Celsius to -20Celsius to -40Celsius)
(liquid saline cryothermia/cryopreservative to -20C)
Cryothermic Atomic Life
(Dry Freeze: -20 to -40C)
(solid sugar cryothermia/cryopreservative to -40C)
(+1C slow freeze or flash freeze: mechanical vibration and electromagnetic field to avoid ice crystals)
Lyophilizer (Dry Freezer)
(antioxidants and cellular membrane stabilizers)
(dry freeze with vacuum sublimation of water)
(unlimited preservation in deoxygenated -40C chamber)
(cellular membrane regenerators)
(cellular rehydration and defrosting)
(AquaHeart: Porous Intercellular Circulation)
(high pressure/gravity "rich" blood chamber)
(Porous "sponge" body filter)
(low pressure/gravity "dirty" blood chamber)
(blood pump, filtration and supplementation)
Cryothermic Genetic Life
(Dry Freeze: -20 a -40C)
(cellular preservation with nuclear DNA)
(cellular nuclear transfer)
(cellular reproduction or reprogramming)
Normothermic Informatic Life
(Dry Environment Temperature: 10C to 30C)
Hardrive and Pendrive
( DNA and Memory binary storage)
(text/audio/video DNA code, history and knowledge)
Pilot and Remote
module wheels and driving system
for aero-aqua-terrestrial transportation
PERMANENT LIFE MODULE
SYSTEMIC LIFE SUB-MODULE
CELLULAR LIFE SUB-MODULE
ATOMIC LIFE SUB-MODULE
PERMANENT LIFE MODULE
Preserve, Regress, Regenerate, Progress:
(Binary DNA-Neural Memory)
Macro Module 1.0
Macro Lab 1.0