FUNGUS

Fungus Prevention-Cure with natural low cost high efficiency IUI Individual Universal Immunotherapy C-Life-IUI-CBM-SAV-SAS-SAT.

Fungus threat is highly underestimated. Fungal diseases cause +3.75 million deaths annually worldwide with significant increase trend. Dangerous/lethal fungi include Aspergillus, Candida, Cryptococcus, Histoplasma and Mucormycosis, cause infections specially with weak immune systems.

Fungi diseases are particularly dangerous for individuals with compromised immune systems, such as those with cancer, HIV/AIDS, organ transplants or chronic respiratory diseases, that may start with viral Flu pneumonia and end up with lethal viral-bacterial-fungal pneumonia under allopathic medicine.

High risk fungal diseases can lead to severe infections, especially in people with weakened immune systems, as Aspergillosis caused by Aspergillus fungus, that lead to severe lung infections. Candidiasis can affect blood, heart, brain, eyes, bones and other parts of the body.

Cryptococcosis caused by Cryptococcus fungi can lead to severe infections, as in the lungs and brain. Histoplasmosis caused by inhaling spores of Histoplasma fungus that is found in bird/bat droppings. Mucormycosis or black fungus can cause severe infections in sinuses, brain and lungs.

C-Life

Cubic Cell Biologic Medicine hardware-software system to coordinate IUI Individual Universal Immunotherapy, CBM Cell Bank Medculture. Seed Blood provides individual blood supplement or extraction containing compatible antibodies, antigen loaded immune cells against fungus/pathogens.

Because fungal infection affects individual with deficient immune system, using in-vivo stimulation of this system as antigen vaccines could result in a deficient response and fungi cells are very similar to Human cells. Ex-vivo supplement of pretested specific antibodies and immune cells can work.

IUI Individual Universal Immunotherapy

Fungal, viral or bacterial pathogens interact with host cells in different ways and the immune system responds to each type differently with a customized immune response, evolving various mechanisms to effectively combat these diverse threats in-vivo, that can be replicated ex-vivo in ideal space/time.

Fungi typically interact with host cells by adhering to the cell surface, which can trigger internalization into the host cell. They can use surface molecules to bind to host extracellular matrix components, facilitating infection intra-cellular/extra-cellular, often secreting enzymes/toxins to invade/damage.

The immune system primarily uses macrophages and neutrophils to combat fungal infections. These cells can phagocytize, engulf and digest fungal cells. T-helper cells as Th1/Th17 also play a crucial role by producing cytokines that enhance the anti-fungal activity of macrophages and neutrophils.

There are no current approved vaccines for fungal infections, but there is research to develop vaccines that could protect against fungal pathogens like Candida, Cryptococcus and Aspergillus. These experimental vaccines often focus on fungal cell wall antigens combined with adjuvants.

There are antibodies that can target fungal pathogens, neutralizing fungi, inhibiting their growth and promoting their clearance by the immune system. Ex-vivo IUI Individual Universal Immunotherapy can produce pre-tested individual antigens, antibodies and antigen loaded immune cells.

The best strategy against fungi or any pathogen is to replicate ex-vivo the in-vivo pathogen infection conditions, but in space-time-quantity-type that are favorable to the immune system leading to defense success ex-vivo to then transfer in-vivo antibodies and antigen loaded immune cells.

Ex-vivo immune cell training strategies involve exposing immune cells to pathogens or their antigens in a controlled ex-vivo environment, helping train the immune cells to recognize and effectively combat the pathogen, producing antibodies against specific fungal antigens and antigen loaded immune cells.

Individual antibodies and antigen loaded immune cells produced ex-vivo can then be administered to patients in-vivo to neutralize the pathogen. Expand pathogen-specific adaptive immune cells as T/B/D cells ex-vivo and then transferring them back into the patient as immunotherapy for fungal infections.

Mucocutaneous candidiasis where Candida infects skin and mucosal membrane surfaces of the host, lymphocytes (TH17, CD8+, ILC3, T cells) that produce cytokines (IL-17 and IL-22) can fight infection. Myeloid phagocytes (neutrophils, macrophages, monocytes) can protect against systemic Candida.

Cryptococcosis inhaled Cryptococcus spores lodge in lungs and disseminate as yeast to the blood brain barrier. TH1 CD4+ T cells can produce protective cytokines (IFN, IL-12, IL-2) to recruit and activate phagocytes (neutrophils, macrophages, monocytes) to intra-cellularly kill cryptococci during infection.

Aspergillosis, a lung infection caused by Aspergillus mold A. fumigatus, CD4+ T cell and myeloid cells (neutrophils, CCR2+ monocytes, plasmacytoid dendritic cells) can protect the lung. Different in-vivo effective immune responses can require ex-vivo supplementation specially for immune deficient.

CBM Cell Bank Medculture

CBM/IUI/C-Life copies in-vivo conditions replicating the in-vivo environment ex-vivo with factors like controlled micro-environment, cytokine-mix, cell-cell interactions. Ex-vivo trained immune cells can attack unhealthy cells with correct antigen ID/load and be replaced by in-vivo or ex-vivo healthy cells.

SAV Super Auto Vaccine

Individual different ex-vivo/in-vivo immune responses against fungal pathogens are needed because individuals most at risk for fungal disease are missing components of innate or adaptive immune system. General or specific fungal vaccine is less efficient than Individual vaccines/supplements.

Fungal cell walls have carbohydrate polymers b-glucans/mannoproteins/chitin on top of the plasma membrane that could act as antigens to stimulate host immune responses combined with adjuvants. Sub-unit peptide or protein sequences offer less risk than live-attenuated or heat-killed cell.

Vaccine against Candida, Cryptococcus, Aspergillus and other fungal pathogens have focused on fungal cell wall antigens that can have enhanced immune response when over expressed in live-attenuated or heat-killed whole cell or safer sub-unit fragments or synthesized peptides.

Knowing what Human cell membrane/protein is vulnerable to fungus and what fungus protein/antigen is vulnerable to Human antibodies and immune cells, can create ex-vivo IUI and/or In-vivo vaccine cure/prevention of antibodies and antigen loaded immune cells, nano/micro intra-skin/venal delivered.

Stock of antibodies for immediate use can enhance the speed/efficiency of fungus treatments, especially in situations where time is critical. It can be tailored to individual needs, taking into account personal health history, environmental exposures and specific vulnerabilities.

SAS Super Auto Supplement

There are several types of healthy/benign fungi that are commonly present in the human body. These fungi are part of the normal microbiota and can play beneficial roles. Some species can cause infections while others are part of the normal gut flora and can coexist without causing harm.

Saccharomyces boulardi yeast is used as a probiotic to support gut health and prevent gastrointestinal disorders. Antibiotics, which are often derived from fungi, like penicillin from Penicillium, primarily target bacteria, but they can indirectly affect (un) healthy fungus and bacteria.

Antibiotics can disrupt/kill beneficial bacteria in the gut microbiome, creating an imbalance that allows pathogenic fungi like Candida to overgrow. Antibiotics can weaken immune response, making it easier for fungal infections to take hold. Bacteria can be target directly by antigen/antibodies/immune cells.

Healthy fungi can compete with pathogenic fungi for resources, potentially reducing or eliminating their presence, out-competing pathogenic fungi for nutrients/space, limiting their growth, helping influence the immune system and enhancing its ability to fight off pathogenic fungi.

SAT Super Auto Test

Mescope, micro-fluid saliva, blood, urine, mucus, sweat, tear can identify pathogens as fungus, toxins, virus, bacteria, cancer, trauma or aging. Proteins/antigens identified via cell phone photonic imaging, accessory lenses, Human Artificial Intelligent enlargement and analysis.