TRAUMA

Trauma Prevention-Cure with natural low cost high efficiency IUI Individual Universal Immunotherapy C-Life-IUI-CBM-SAV-SAS-SAT.

Over 5 Million Lives are abandoned per year globally because of trauma, from injuries/violence, including accidents/unintentional injuries, as traffic crashes/falls/drowning, violence, intentional injuries, such as over 500,000 homicides and 1,000,000 suicides, with lethal weapons facilitating these numbers.

Lethal weapons are unnecessary excessive use of force, damaging and illegal, since there are more efficient non-lethal weapons. Banning lethal weapons, upholding freedom, economic development, Human Rights, high education, psychological assistance can reduce homicides and suicides.

Once trauma has been inflicted, traditional allopathic medicine will use anti-symptomatic drugs and macro surgery to limit perceived damage. Mini-Micro-surgery can improve macro surgery and immune, stromal, stem cells supplemented ex-vivo can supplement/accelerate in-vivo regeneration.

Permanent Life Biologic Medicine can use whole body or segment of body circulation for oxygen and nutrients to reach cells, overcoming any vascular obstruction caused by trauma, including using mini/micro catheters, multiple heart/blood pumps, blood oxygenation and nutrition.

In-vivo immune system helps regenerate trauma and ex-vivo supplementation helps accelerate and improve this regeneration. The in-vivo immune system plays an essential role in trauma regeneration via coordinated processes of inflammation, stem cell activation and inflammation reduction.

Trauma generates inflammation, immune cells, as macrophages/neutrophils, enter injury site helping clear debris/pathogens, set up tissue repair, release cytokines/growth factors, activate resident Stem Cells to proliferate/differentiate into functional cells, replace damaged tissue to then reduce inflammation.

Resident stem cells migrate from nearby bone marrow and tissues can contain local stem cells since embrionic development. Tissues use their own resident stem cells, that have been present since embryonic development, for tissue maintenance/repair, as muscle and neural stem cells.

Trauma to the spinal cord near the neck or near the hip can cause paraplegia/tetraplegia, paralysis of lower or lower/upper members, legs or arms/legs. Nerves, cable-like network formed by Neuron Axons structured/surrounded by Schwann cells/lipid-rich Myelin are severed and usually do not regenerate.

Reconnecting/regenerating severed Nerves may require an ex-vivo scaffold, as aero-graphene, to replicate nature, Stem cell derived Neurons can be introduced, protected, stimulated by temporary artificial electro-chemical signals and training so that natural system/signal can regenerate/re-function.

Super-Neuron and Super-Nerve can be built ex-vivo and/or in-vivo to repair trauma damage using aero-graphene, a 3D cylindrical nano-tube of 2D one-layer carbon graphene, that can be obtained by pressurized heat of a hydrocarbon to obtain graphene oxide followed by vacuum/laser deoxygenation.

Bio-Cyber Super-Nerve creates redundant double bio/cyber electric signal stimulus for regeneration of paraplegic/quadriplegic spinal cord trauma severance, using aero-graphene scaffold for stem cell derived neurons eletric current stimulated, wireless electric sensor/signaler on brain and severance points.

C-Life

Cubic Cell Culture, Biologic Medicine, hardware-software system to coordinate IUI Individual Universal Immunotherapy and CBM Cell Bank Medculture. Seed Blood provides ex-vivo individual blood culture supplements for Trauma, as compatible antibodies, antigen loaded immune cells and stromal/stem cells.

Mini/micro catheters can deliver Stem, Stromal, Immune, Functional Cells to injury/trauma sites to accelerate regeneration, navigating via mini/micro incisions, vascular system and inter-cellular spaces. Ability to bind/contribute to tissue repair depends on cell type/function and signal proteins/receptors.

C-Life-Super-Nerve
Paraplegic-Quadriplegic
Aero-Graphene-Scaffolds
Spinal-Cord-Reconnection
Reconnect-Severed-Nerves
Scaffold-Stem-Cell-Neurons
Stimulating-Electron-Current
Scaffold-Neurons-Regrowing
Action-Stimulation-Reconnection
Brain-Nerve-Electric-Sensor-Signal

IUI Individual Universal Immunotherapy

In-vivo Hematopoietic Stem Cells from bone marrow for example migrate to tissues during injury/stress traveling through bloodstream to reach and repair damage. Cultured ex-vivo Immune/Stromal/Stem Cells can migrate in bloodstream to injury sites or bone marrow via arteries/veins/capillaries and catheters.

Immune/Stromal/Stem Cell blood migration can be influenced by cell size, surface markers and signaling molecules. Most Stem Cells can navigate via capillaries, but to reach specific tissues or injury sites may depend on receptor/adhesion molecules interacting with vessel endothelial cells.

Mesenchymal Stem/Stromal Cells converge to injury sites and contribute to tissue repair through differentiation and secretion of bio-active molecules. Binding/Integration of these cells require specific signal proteins/receptors, as stromal/immune cells ligand-receptor function/position interactions.

Local tissue micro-environment as inter-cellular space components and other cells, help integration and function of delivered in-vivo and/or ex-vivo stromal, stem and/or functional cells. Catheters deliver therapeutic cells to injury sites with specific signals/micro-environment to bind/function in tissue repair.

CBM Cell Bank Medculture

Ex-vivo Immune/Stromal/Stem Cell Culture can replicate and accelerate in-vivo trauma regeneration, with high probability that cells supplemented are healthy, contrary to in-vivo regeneration stimulus that needs to eliminate unhealthy cells, as cancer/pathogen controlled, before in-vivo re-stimulation.

Ex-vivo Individual Cell Bank Medculture has compatibility with donor, avoids issues of rejection because of DNA mismatch and must replicate in-vivo conditions of continuous cell replication as a living cell culture, used for trauma when needed, also be dry-cryo-frozen for lower cost/turn around longevity.

SAV Super Auto Vaccine

Micro/nano supplementation of antigens/antibodies/mRNA can create better conditions for in-vivo and ex-vivo supplementation regeneration. Trauma creates vulnerable conditions for pathogens to replicate and become a secondary threat to the injured biologic tissue, organ and body.

SAS Super Auto Supplement

Ex-vivo supplementation can reinforce/accelerate the natural regenerative process. Stem/stromal cell culture outside body increases number of cells to be reintroduced into injury site. Cytokines/growth factors, as fibroblast growth factor FGF-2/B-27, can improve muscle or functional cells recovery.

Functional in-vivo local cells or ex-vivo arriving cells can signal/induce via mRNA exosomes to stromal/stem cell to differentiate into specific cell types, as functional local muscle/neuron cells. Exosomes are extracellular vesicles carrying mRNA, miRNA, proteins, lipids to reform recipient cells.

Mesenchymal Stem Cells release exosomes that can transfer mRNA and other signaling molecules to target cells, changing gene expression and promoting differentiation into specific cell types. In the process of cell-to-cell communication/regeneration, exosomes are key in tissue repair/regeneration.

SAT Super Auto Test

Mescope, micro-fluid saliva, blood, urine, mucus, sweat, tear can identify pathogens as virus, bacteria, cancer, fungus, toxins or aging, as secondary/primary threat in trauma. Proteins/antigens identified via cell phone photonic imaging, accessory lenses, Human Artificial Intelligent enlargement and analysis.