BACTERIA

Bacteria Infection Prevention-Cure with natural low cost high efficiency IUI Individual Universal Immunotherapy C-Life-IUI-CBM-SAV-SAS-SAT.

Over 7 million Lives yearly are abandoned because of bacterial infection, including Tuberculosis,
Pneumococcal Disease, Diphtheria, Tetanus, Pertussis, Haemophilus influenzae type B, Meningococcal Disease, with vaccines available.

Main bacterial diseases without vaccines could include also Tuberculosis because vaccine real world efficiency is limited/variable, Staphylococcus Aureus Infections, Gonorrhea, Cholera, Lyme Disease, Leprosy, Syphilis and Urinary Tract Infections.

Bacterial Gastroenteritis, as from Escherichia coli, Salmonella, Shigella could lead to bacteria entering bloodstream, also in Appendicitis/Peritonitis, abdominal cavity, Diverticulitis, inflammation/infection of small pouches in digestive system, if it ruptures can lead to bacteria entering blood stream.

Bacteria can out replicate immune response with fast growth, multiplying quickly, as doubling in numbers every 20 minutes, under optimal conditions for them, or non-optimal for Humans, as low temperature/nutrition/hydration/rest, overwhelming the immune system at specific time/space.

Bacteria in-vivo can form biofilms, protective layers helping them adhere to surfaces, resist immune attacks and antibiotics, or produce capsules, thick outer layer protecting from being engulfed by immune cell phagocytosis, but ex-vivo immune system optimal conditions can extract antigens.

Bacteria can change surface proteins to avoid being recognized by the immune system, with antigen variation requiring new adaptation. Partial vaccination or partial antibiotic treatment, allow hosts to create surviving/mutation antigen varying bacteria, but full use of vaccine/antibiotics can avoid this.

Bacteria intracellular survival, living inside host cells, allows them to hide from the immune system, as Mycobacterium Tuberculosis, surviving inside macrophages in-vivo, requiring ex-vivo strategy to reduce, not use or eliminate macrophages, replaced temporarily by expanding other immune cells.

Bacteria secretion systems, as from Salmonella/E. coli, inject proteins into host cells, disrupting in-vivo immune responses, that may be countered by ex-vivo strategies to identify/target antigens on the surface of these bacteria, a strategy to disrupt their secretion systems or the cell reception points.

Bacteria enzyme production can break down immune molecules, as Staphylococcus Aureus producing coagulase, clotting blood plasma, creating barrier against immune cells in-vivo, that can be countered ex-vivo by making these enzymes or surface components antigen targets for antibodies.

Bacteria toxin production can damage host tissues and immune cells, helping their evasion and spreading in-vivo, but this also can be neutralized ex-vivo, by making surface components and/or these toxins antigens for antibodies, antigen loaded immune cells created ex-vivo to introduce in-vivo.

Bacteria, virus or fungal pathogens interact with host cells in different ways and the immune system responds to each type differently with a customized immune response evolving various mechanisms to effectively combat these diverse threats in-vivo that can be replicated ex-vivo in ideal space/time.

Bacteria pathogen can be either intracellular or extracellular. Extracellular bacteria often adhere to host cells using pili/fimbriae and secrete toxins that damage tissues. Intracellular bacteria invade host cells and replicate within them, often evading the immune response.

Immune system for extracellular bacteria, can use Neutrophils and Macrophages to engulf and destroy bacteria. Antibodies can neutralize toxins and transform bacteria, making them easier to phagocytize. For intracellular bacteria, cytotoxic T cells and Macrophages to eliminate a contaminated cell.

C-Life Cubic Cell Culture Life

Biologic Medicine hardware-software system to coordinate IUI Individual Universal Immunotherapy and CBM Cell Bank Medculture. Seed blood expanded ex-vivo to provide individual blood supplementation containing compatible antibodies and antigen loaded immune cells to attack bacteria in-vivo.

IUI Individual Universal Immunotherapy

Bacterial infections are a product of them being able to outreplicate/outnumber immune response and because they have developed particular strategies to avoid immune detection or attack. Individual Universal Immunotherapy can test both possibilities, starting with quantity/quality of immune response.

Partial use of antibiotics, anti-bacterial drugs, vaccination can lead to hosts with surviving/mutating Super-Bacteria resistance. Bacteria antigens from their membrane can be fully/generally used as in-vivo vaccines and to produce ex-vivo antigens, antibodies, antigen loaded immune cells for IUI.

IUI can manage the quality/quantity of response in terms of matching particular quantities of particular antibodies and immune cells to particular low count bacteria. Match could be made for in-vivo perfect space/time to stop bacteria infection, which may not happen in-vivo but can happen ex-vivo.

Efficiency of immune response in matching specific antibodies and immune cells to particular bacteria, in terms of quantity/quality, in specific space/time, is crucial in stopping infections. Having a redundancy ex-vivo system can raise efficiency of Human Immune system from +95% to +99.99%.

The immune system recognizes bacteria using antigens, which are unique molecules on the surface of pathogens. Dendritic cells and Macrophages present these antigens to T cells. Once T cells recognize the antigens, they become activated and helper T-cells activate B cells to produce specific antibodies.

Antibodies bind to the antigens on the bacteria surface, neutralizing the bacteria or marking them for elimination by other immune cells. After the infection, some B and T cells become memory cells, which can respond more rapidly and effectively if the same bacteria infect the body again.

If the immune system quickly matches the correct antibodies and immune cells to the bacteria, it can prevent the bacteria from multiplying and spreading. Time and space are crucial for that to happen and that may not always take place in-vivo but can always happen in a created controlled ex-vivo setting.

Early efficient immune responses can stop infections before they become severe or systemic, spreading throughout the body. Timely immune response reduces severity of symptoms and prevents complications such as so called sepsis, avoidable with ex-vivo army of immune cells and antibodies.

IUI Individual Universal Immunotherapy and CBM, Cell Bank Medculture for bacteria infection
(also for Virus, Cancer, Fungus, Toxin, Trauma and Aging):

Ex-vivo Exposure: Bacteria are exposed to a controlled environment outside the body, ex-vivo, where they can be identified and analyzed.

Antigen Extraction: Specific antigens from the bacteria are extracted and used to stimulate an immune response.

Antigen Loading: These antigens are loaded onto immune cells, such as Dendritic D, T, B cells, to present them efficiently to the immune system and compatible with the original donor and infected.

Antibody Production: The immune system is stimulated to produce a wide range of antibodies specific to the bacterial antigens and compatible with the original donor and infected.

Reintroduction In-vivo: The enhanced immune response, including the activated immune cells and antibodies, are reintroduced into the body to target and eliminate the bacteria, tested ex-vivo.

Individual Treatment: Creating the specific immune response to the specific bacteria infecting an individual leads to more efficient treatments, less/no collateral effect, with compatible antibody/cells.

Enhanced Immune Response: Optimizing and supplementing ex-vivo the timing and quality of the immune response in-vivo, body more efficiently combats infection with compatible cells/antibodies.

Reduced Resistance: There is reduction in the probability of bacteria developing resistance, as the immune system would be highly targeted and adaptable, specially with general/full treatment.

Broad Applicability: System used for all bacterial infections, including those with/without existing vaccines and for other pathogens/conditions as virus, cancer, fungus, toxin, trauma and aging.

CBM Cell Bank Medculture

Immune Cells, Antibodies and Antigens can be produced by permanent multi-function individual Cell Bank Medculture, that includes supplementing in-vivo defense system against Bacteria with ex-vivo space-time-quantity-type variable control, raising +95% in vivo efficiency to +99,99%.

SAV Super Auto Vaccine

General Antigen and Individual Antibody produced by Individual IUI/CBM cell bank, identifying antigen of Bacteria, via multi-strategies proven ex-vivo, loaded into nano intra-skin delivery auto-applied system, at contagion/contaminant point, as skin patch, sublingual pill, eye drop and/or nasal spray.

SAS Super Auto Supplement

Ex-vivo produced nano Human mRNA to produce Human Proteins to produce supplements to help Revoking, Repairing, Replacing, Reforming, Replicating cells. Intra-venal antigen loaded immune cells (B/T/D) can supplement bacteria cure/prevention/regeneration, as also stromal cells, macro-proteins.

SAT Super Auto Test

Mescope, microfluid saliva, blood, urine, mucus, sweat, tear, can identify bacteria, proteins/antigens via photonic imaging of cell phone, accessory lenses and network HAI, Human Artificial Intelligent enlargement/analysis, complemented by mini testing in mini-laboratory.